Accuracy of positron emission tomography/computed tomography to detect para-aortic lymph node metastases in selected series with locally advanced cervical cancer
| Series | N | FIGO stage 2009 | PALN metastases without para-aortic uptake (n (%))* | PALN metastases with pelvic uptake (%)* | Sensitivity (%) | Specificity (%) | PPV (%) | NPV (%) |
| Leblanc 201136 | 125 | IB2–IVA | 14 (10.4) | 20 | 33 | 94 | 54 | 88 |
| Uzan 201148 | 96 | IIB–IVA | 8 (8.4) | 24Le | NR | NR | NR | 92 |
| Ramirez 201167 | 60 | IB2–IVA | 14 (23) | 22 | 36 | 96 | 71 | 83 |
| Gouy† 20134 | 237 | IB2–IVA | 29 (12) | NR | NR | N/R | N/R | 88 |
| Martinez† 202029 | 125 | IB2–IVA | 17 (13.6) | 27 | NR | N/R | N/R | 86.4 |
| De Cuypere 202068 | 168 | IB2–IVA | 26 (17.2) | 22.4 | 24 | 93 | 47 | 83% |
*PALN metastases histologically confirmed in patients without para-aortic lymph node uptake on PET/CT.
†Only included patients with negative para-aortic lymph node uptake.
FIGO, International Federation of Gynecology and Obstetrics; N, number of patients in the study; NPV, negative predictive value; NR, not reported; PALN, para-aortic lymph node metastases; PET/CT, positron emission tomography/computed tomography; PPV, positive predictive value.