Selected characteristics of patients that underwent radical hysterectomy for stage IB1 cervical carcinoma, by surgical approach, before and after inverse probability of treatment weighting
| Before inverse probability weighting | After inverse probability weighting | |||||
| Baseline characteristics | Open surgery (n=402) | Minimally inv. surgery (n=291) | P-value | Open surgery (n=402) | Minimally inv. surgery (n=291) | P-value |
| Age—yr | 48.50 (10.60) | 47.93 (11.51) | 0.51 | 48.31 (10.75) | 48.10 (11.26) | 0.80 |
| Body-mass index—kg/m2 | 25.98 (4.73) | 25.49 (5.62) | 0.27 | 25.92 (5.51) | 25.92 (4.81) | 0.48 |
| Performance status ECOG (%) | 0.15 | 0.29 | ||||
| PS 0 | 351 (87.31) | 256 (87.97) | 353 (87.81) | 257 (88.31) | ||
| PS1 | 41 (10.19) | 20 (6.87) | 37 (9.20) | 20 (6.87) | ||
| Not reported | 10 (2.48) | 15 (5.15) | 12 (3.89) | 14 (4.81) | ||
| Preoperative clinical size (%) | <0.001 | 0.058 | ||||
| Not evaluable | 8 (1.99) | 11 (3.78) | 8 (1.95) | 12 (4.12) | ||
| ≤2 cm | 152 (37.81) | 151 (51.89) | 153 (38.10) | 150 (52.54) | ||
| >2 cm | 242 (60.20) | 126 (43.29) | 241 (59.95) | 126 (43.29) | ||
| Not reported | 3 (1.03) | 3 (1.03) | ||||
| Radical histerectomy pathology report | ||||||
| Largest diameter in path-report (mm) | 24.07 (10.13) | 22.57 (9.46) | 0.05 | 23.66 (9.99) | 23.15 (9.60) | 0.501 |
| Largest tumor diameter (%) | 0.270 | 0.941 | ||||
| ≤2 cm | 160 (39.80) | 128 (43.99) | 168 (41.63) | 120 (41.35) | ||
| >2 cm | 242 (60.20) | 163 (56.01) | 235 (58.37) | 170 (58.65) | ||
| Final histological grade (%) | 0.266 | 0.983 | ||||
| Grade 1 | 59 (14.68) | 42 (14.43) | 59 (14.65) | 43 (14.71) | ||
| Grade 2 | 197 (49.0) | 130 (44.67) | 188 (46.66) | 135 (46.54) | ||
| Grade 3 | 115 (28.61) | 101 (34.71) | 127 (31.57) | 91 (31.39) | ||
| Not reported | 31 (7.71) | 18 (6.19) | 29 (7.12) | 21 (7.36) | ||
| Lymphovascular space invasion (LVSI) (%) | 0.061 | 0.990 | ||||
| No LVSI | 187 (46.52) | 165 (56.70) | 204 (50.60) | 147 (50.55) | ||
| Presence of LVSI | 162 (40.30) | 105 (36.08) | 156 (38.61) | 111 (38.39) | ||
| Not reported | 53 (13.18) | 21 (7.22) | 43 (10.80) | 32 (11.06) | ||
| Depth of Invasion (%) | 0.069 | 0.998 | ||||
| Superficial <1/3 | 77 (19.15) | 65 (22.34) | 81 (20.23) | 59 (20.24) | ||
| Intermediate>1/3 and <1/3 | 135 (33.58) | 75 (25.77) | 121 (30.11) | 87 (29.86) | ||
| Deep >2/3 | 131 (32.59) | 68 (23.37) | 116 (28.77) | 85 (29.31) | ||
| Not reported | 59 (14.68) | 83 (28.52) | 84 (20.89) | 59 (20.59) | ||
| Margins status (%) | 0.151 | 0.954 | ||||
| Negative | 357 (88.81) | 268 (92.10) | 364 (90.13) | 262 (90.13) | ||
| Positive or close <2 mm | 45 (11.19) | 23 (7.90) | 39 (9.74) | 29 (9.87) | ||
| Lymph node status (%) | 0.106 | 0.916 | ||||
| Negative | 336 (83.58) | 256 (87.97) | 345 (85.74) | 248 (85.45) | ||
| Positive | 66 (16.42) | 35 (12.03) | 57 (14.26) | 43 (14.55) | ||
| FIGO staging 2018 (%) | 0.015 | 0.129 | ||||
| IB1 | 118 (29.35) | 116 (39.86) | 126 (31.18) | 107 (36.71) | ||
| IB2 | 207 (51.49) | 129 (44.33) | 210 (52.13) | 129 (44.28) | ||
| II-III<4 cm | 77 (19.15) | 46 (15.81) | 67 (16.69) | 55 (19.01) | ||
| Post-adjuvant therapy (%) | 0.002 | 0.776 | ||||
| None | 166 (41.29) | 154 (52.92) | 191 (47.31) | 140 (48.40) | ||
| Yes | 236 (58.71) | 137 (47.08) | 212 (52.69) | 150 (51.60) | ||
Counts in the weighted cohort may not sum to expected totals owing to rounding. Percentages may not total 100 because of rounding, and disagreements between numbers and percentages in the weighted cohort are the result of rounding of noninteger number values. Distributions of categorical variables were compared using the chi-square test in the unweighted cohort and weighted logistic-regression models in the weighted cohort. Quantitative variables were compared using the student t-test in the unweighted cohort and weighted linear-regression models in the weighted cohort.