Clinicopathologic and surgical characteristics of patients with vulvar cancer (n=1727)
| Characteristic | All cases (n=1727) n (%) | Squamous (n=1535) n (%) |
| Age (years) (mean±SD) | 70±12.8 | 71±12.3 |
| Smoking | ||
| Yes | 135 (7.8) | 116 (7.6) |
| No | 907 (52.5) | 837 (54.5) |
| Unreported | 685 (39.7) | 582 (37.9) |
| Human papillomavirus | ||
| Yes | 130 (7.5) | 127 (8.3) |
| No | 475 (27.5) | 416 (27.1) |
| Unreported | 1122 (65.0) | 992 (64.6) |
| Previous vulvar lesion | ||
| No | 517 (29.9) | 451 (29.4) |
| Lichen sclerosus | 224 (13) | 217 (14.1) |
| Vulvar intraepithelial neoplasia | 160 (9.3) | 157 (10.2) |
| Unreported | 826 (47.8) | 710 (46.3) |
| Histologic type | ||
| Squamous | 1535 (88.9) | 1535 (100) |
| Melanoma | 42 (2.4) | – |
| Paget’s disease | 38 (2.2) | – |
| Other | 112 (6.5) | – |
| Lesions (n) | ||
| 1 | 1460 (84.5) | 1330 (86.6) |
| >1 | 267 (15.5) | 205 (13.4) |
| Size of tumor (mm) | ||
| ≤20 | 435 (25.2) | 395 (25.7) |
| >20 | 783 (45.3) | 716 (74.3) |
| Midline affectation | 748 (43.3) | 715 (46.6) |
| FIGO stage (2009) | ||
| IA | 213 (12.3) | 187 (12.2) |
| IB | 628 (36.4) | 559 (36.4) |
| II | 35 (2) | 225 (14.7) |
| IIIA | 153 (8.9) | 151 (9.8) |
| IIIB | 129 (7.5) | 123 (8) |
| IIIC | 81 (4.7) | 82 (5.3) |
| IVA | 50 (2.9) | 50 (3.3) |
| IVB | 16 (0.9) | 12 (0.8) |
| Vascular invasion | ||
| Yes | 207 (12) | 197 (12.8) |
| No | 597 (34.6) | 541 (35.2) |
| Depth of stromal invasion (mm) | ||
| ≤5 | 928 (53.7) | 824 (53.7) |
| >5 | 762 (44.1) | 711 (46.3) |
| Histopathologic margin (mm) | ||
| ≤15 | 1325 (76.7) | 1196 (77.9) |
| >15 | 394 (22.8) | 339 (22.1) |
| Nuclear grade | ||
| G1 | 452 (26.2) | 437 (28.5) |
| G2 | 395 (22.9) | 389 (25.3) |
| G3 | 144 (8.3) | 133 (8.7) |
| Unreported | 736 (42.6) | 576 (37.5) |
| Surgical procedure | ||
| Skinning | 20 (1.2) | 17 (1.1) |
| Local wide excision | 309 (17.9) | 234 (15.2) |
| Vulvectomy | 1246 (72.1) | 1174 (76.5) |
| Exenteration | 10 (0.6) | 7 (0.5) |
| None | 142 (8.2) | 103 (6.7) |
| Sentinel node procedure | ||
| Yes | 244 (14.1) | 229 (14.9) |
| No | 1483 (85.9) | 1306 (85.1) |
| Lymphadenectomy | ||
| Yes | 1038 (60.1) | 997 (64.9) |
| No | 689 (39.9) | 538 (35.1) |
| Unilateral lymph node dissection | 193 (11.2) | 177 (11.5) |
| Bilateral lymph node dissection | 711 (41.2) | 694 (45.2) |
| Superficial lymphadenectomy | 224 (13) | 221 (14.4) |
| Deep lymphadenectomy | 490 (28.4) | 465 (30.3) |
| Positive nodes | 279 (16.2) | 274 (17.9) |
| Bilateral | 80 (4.6) | 78 (5.1) |
| Ipsilateral | 187 (10.8) | 184 (11.9) |
| Contralateral | 12 (0.7) | 12 (0.8) |
| Radiotherapy | ||
| Yes | 67 (39.1) | 659 (42.9) |
| No | 1052 (60.9) | 876 (57.1) |
| Chemotherapy | ||
| Yes | 115 (6.7) | 103 (6.7) |
| No | 984 (57) | 1432 (93.3) |
FIGO, Federation of Gynecology and Obstetrics.