Severity | Management |
Grade 1 | Continue treatment Consider dose interruptions or reductions if considered clinically intolerable by the patient, despite adequate symptom management |
Grade 2 | Continue treatment Consider dose interruptions or reductions if it does not improve with symptom management, or if considered clinically intolerable by the patient |
Grade≥3 where prophylaxis is not feasible or AE persists despite treatment | Withhold for a maximum of 28 days or until resolution of adverse reaction; then, consider dose reduction. |
Grade ≥3 lasting >28 days on the lowest dose-level | If AE persists despite adequate management, permanently discontinue medication |
AE, adverse event.