Characteristic | Total (n=20)* | POPF (n=14) | No POPF (n=6) | P value |
Median age at diagnosis (years) (range) | 69 (32–77) | 69 (59–77) | 62.5 (32–72) | N/S |
Median volume of ascites (mL) (range) | 500 (0–5000) | 100 (0–3000) | 2500 (0–5000) | N/S |
Surgery indication (n (%)) | ||||
PDS | 10 (50.0) | 5 (35.7) | 5 (83.3) | N/S |
IDS | 8 (40.0) | 7 (50.0) | 1 (16.7) | |
Recurrence | 2 (10.0) | 2 (14.3) | 0 | |
Histology (n (%)) | ||||
High-grade serous | 18 (90.0) | 13 (92.8) | 5 (83.3) | N/S |
Others | 2 (10.0) | 1 (7.2) | 1 (16.7) | |
Intra-operative complications (CTCAE 4.03) (n (%))15 | ||||
Grade 3 | 0 | 0 | 0 | N/S |
Grade 4 | 0 | 0 | 0 | |
Grade 5 | 0 | 0 | 0 | |
Post-operative complications (Clavien–Dindo) (n (%))16 | ||||
Grade 1 | 2 (12.5) | 1 (7.2) | 1 (16.7) | |
Grade 2 | 10 (62.5) | 8 (57.1) | 2 (33.3) | N/S |
Grade 3 | 1 (6.2) | 1 (7.2) | 0 | |
Grade 4 | 2 (12.5) | 2 (14.3) | 0 | |
Grade 5 | 1 (6.2) | 1 (7.2) | 0 | |
Technique to seal the pancreatic stump (n (%)) | ||||
Hand-sewn suture | 5 (25.0) | 4 (28.6) | 1 (16.7) | N/S |
Stapler (± suture reinforcement) | 3 (15.0) | 2 (14.3) | 1 (16.7) | |
LigaSure Impact | 6 (30.0) | 4 (28.6) | 2 (33.3) | |
N/A or N/R | 6 (30.0) | 4 (28.6) | 2 (33.3) | |
Median white cells on post-operative days 3–5 (109/L (range) | 17.3 (9.3–32.7) | 19.2 (9.3–32.7) | 17.0 (14.5–22.1) | N/S |
Median time of LUQ drain stay (days from surgery) (range) | 6 (3–31) | 12 (4–31) | 5 (3–6) | 0.008 |
Median value of drain fluid amylase on post-operative days 3–5 (U/L) (range) | 810.5 (9–51 229) | 1949.5 (244–51 229) | 10 (9–136) | N/S |
Median value of serum amylase on post-operative days 3–5 (U/L) (range) | 29 (10–144) | 29 (10–144) | 29 (16–37) | N/S |
Grade of POPF (n (%))13 | ||||
BL | 8 (40.0) | 8 (57.1) | N/A | N/A |
Grade B | 4 (20.0) | 4 (28.6) | N/A | |
Grade C | 2 (10.0) | 2 (14.3) | N/A | |
Symptoms of POPF (n (%)) | ||||
Yes | 5 (25.0) | 5 (35.7) | N/A | N/A |
No | 9 (45.0) | 9 (64.3) | N/A | |
Treatment of POPF (n (%)) | ||||
Octreotide | 4 (20.0) | 4 (28.6) | N/A | N/A |
Octreotide + TPN | 1 (5.0) | 1 (7.1) | N/A | |
None | 9 (45.0) | 9 (64.3) | N/A | |
Median time from surgery to drainage of POPF (days) (range) | 27 (10–32) | 27 (10–32) | N/A | N/A |
Median hospitalization length (days) (range) | 11.5 (7–38) | 16.5 (7–38) | 10 (7–15) | 0.019 |
LUQ drain fluid culture (n (%)) | ||||
Positive | 4 (20.0) | 4 (28.6) | 0 | N/S |
Negative | 9 (45.0) | 5 (35.7) | 4 (66.7) | |
Not performed | 7 (35.0) | 5 (35.7) | 2 (33.3) | |
Median time from surgery to chemotherapy (days) (range) | 56 (27–79) | 60 (27–79) | 46 (35–56) | N/S |
*Information available for 20 patients: two patients did not measure drain fluid amylase – one of them did not have LUQ drain.
BL, biochemical leak; CTCAE, Common Terminology Criteria for Adverse Events; IDS, interval debulking surgery; LUQ, left upper quadrant; N/A, not applicable; N/R, not reported; N/S, not statistically significant; PDS, primary debulking surgery; POPF, post-operative pancreatic fistula; TPN, total parenteral nutrition.