Variables |
BRCA-negative (n=66) |
BRCA1-positive (n=32) |
BRCA2-positive (n=37) | P value |
Gynecological data | ||||
Age at menarche, years, mean±SD | 13.1±1.6 | 12.1±2.5 | 12.6±1.7 | 0.145 |
Regular menses (%) | 50 (75.8) | 24 (75) | 30 (81.1) | 0.787 |
Hormonal contraceptive users (%) | 47 (71.2) | 21 (65.7) | 27 (73.0) | 0.783 |
Contraceptive pill/oral contraceptives (%) | 40 (85.1) | 18 (85.7) | 19 (70.4) | |
Intra-uterine device (levonorgestrel) (%) | 1 (2.1) | 0 | 0 | |
Vaginal ring (%) | 1 (2.1) | 1 (4.8) | 1 (3.7) | |
Transdermal patch (%) | 1 (2.1) | 0 | 0 | |
Combination (%) | 4 (8.5) | 2 (9.5) | 7 (25.9) | |
Hormonal contraception users at AMH analysis (%) | 21/66 (31.8) | 10/32 (31.2) | 13/37 (35.1) | 0.901 |
Duration of contraceptive treatment, years, mean±SD | 5.0±5.7 | 4.4±5.5 | 4.8±5.2 | 0.554 |
Reproductive data | ||||
Childbirths, median (range) | 1 (0–4) | 1 (0–3) | 2 (0–3) | 0.854 |
Spontaneous abortion, median (range) | 0 (0–2) | 0 (0–2) | 0 (0–3) | 0.062 |
Nulliparous | 20 (30.3) | 7 (21.9) | 13 (35.1) | 0.478 |
Not tried to conceive | 18 | 5 | 11 | |
Infertility | 1 | 1 | 1 | |
Currently pregnant | 1 | 1 | 1 | |
Age at first birth, mean±SD | 29.0±7.8 | 30±7 | 31±7.2 | |
Age at last birth, mean±SD | 31.4±6.8 | 32±6.5 | 32±6.2 | |
Women who tried to conceive | 48 | 27 | 26 | |
Infertility (%) | 9 (18.7) | 6 (22.2) | 8 (30.8) | 0.499 |
Unknown cause (%) | 5 (55.6) | 0 | 4 (50) | |
Age >39 years (%) | 1 (11.1) | 3 (50) | 2 (25) | |
Male cause (%) | 1 (11.1) | 0 | 1 (12.5) | |
Polycystic ovary syndrome (%) | 1 (11.1) | 2 (33.3) | 0 | |
Myomatosis (%) | 0 | 0 | 1 (12.5) | |
Endometriosis (%) | 1 (11.1) | 1 (16.7) | 0 | |
Infertility treatment (%) | 7 (14.6) | 3 (11.1) | 5 (19.2) | |
Artificial insemination (AI) | 3 | 0 | 3 | |
In vitro fertilization (IVF) | 3 | 1 | 1 | |
AI-IVF | 1 | 2 | 2 |
Data as frequencies and percentages in parenthesis unless otherwise stated.
AMH, anti-müllerian hormone.