Univariable analysis of clinicopathologic characteristics on recurrence-free survival and overall survival
| Variable | n (%) | Recurrence-free survival | Overall survival | ||
| HR (95% CI) | P value | HR (95% CI) | P value | ||
| Age, as continuous variable | 5181 | 1.017 (1.010 to 1.024) | <0.001* | 1.024 (1.016 to 1.032) | <0.001* |
| FIGO stage | |||||
| IA2 | 62 (1.2) | Reference | Reference | ||
| IB1 | 2482 (47.9) | 3.082 (0.767 to 12.393) | 0.113 | 3.750 (0.525 to 26.798) | 0.188 |
| IB2 | 388 (7.5) | 6.938 (1.703 to 28.259) | 0.007* | 9.130 (1.261 to 66.092) | 0.029* |
| IIA1 | 1598 (30.8) | 7.241 (1.804 to 29.068) | 0.005* | 10.029 (1.407 to 71.488) | 0.021* |
| IIA2 | 651 (12.6) | 9.342 (2.316 to 37.681) | 0.002* | 13.966 (1.951 to 99.972) | 0.009* |
| Histopathologic- al type | |||||
| SCC | 4510 (87.0) | Reference | Reference | ||
| AC | 488 (9.4) | 1.509 (1.225 to 1.859) | <0.001* | 1.710 (1.344 to 2.175) | <0.001* |
| ASC | 183 (3.5) | 1.994 (1.495 to 2.658) | <0.001* | 2.151 (1.538 to 3.009) | <0.001* |
| Tumor size (cm), as continuous variable | 5181 | 1.238 (1.192 to 1.287) | <0.001* | 1.275 (1.220 to 1.333) | <0.001* |
| Depth of stromal invasion | |||||
| ≤1/3 | 1484 (30.6) | Reference | Reference | ||
| >1/3 and ≤2/3 | 1640 (33.8) | 1.954 (1.556 to 2.454) | <0.001* | 2.237 (1.656 to 3.021) | <0.001* |
| >2/3 | 1729 (35.6) | 3.841 (3.113 to 4.739) | <0.001* | 5.245 (3.983 to 6.907) | <0.001* |
| Lymphovascular space invasion | |||||
| No | 3006 (62.9) | Reference | Reference | ||
| Yes | 1770 (37.1) | 2.927 (2.534 to 3.381) | <0.001* | 3.436 (2.880 to 4.101) | <0.001* |
| Peripheral nerve infiltration | |||||
| No | 4274 (91.6) | Reference | Reference | ||
| Yes | 393 (8.4) | 1.971 (1.602 to 2.424) | <0.001* | 2.245 (1.772 to 2.846) | <0.001* |
| Parametrial invasion | |||||
| No | 4457 (91.7) | Reference | Reference | ||
| Yes | 401 (8.3) | 3.959 (3.338 to 4.695) | <0.001* | 4.307 (3.532 to 5.252) | <0.001* |
| Vaginal margin involvement | |||||
| No | 4764 (98.8) | Reference | Reference | ||
| Yes | 58 (1.2) | 3.643 (2.444 to 5.430) | <0.001* | 3.484 (2.148 to 5.652) | <0.001* |
| Pelvic lymph node metastasis | |||||
| No | 3761 (76.6) | Reference | Reference | ||
| Yes | 1149 (23.4) | 3.439 (2.982 to 3.966) | <0.001* | 3.970 (3.346 to 4.709) | <0.001* |
| Para-aortic lymph node metastasis | |||||
| No | 640 (85.4) | Reference | Reference | ||
| Yes | 109 (14.6) | 4.277 (3.154 to 5.798) | <0.001* | 4.390 (3.088 to 6.240) | <0.001* |
*P<0.05.
AC, adenocarcinoma; ASC, adenosquamous carcinoma; CI, confidence interval;FIGO, International Federation of Gynecology and Obstetrics; HR, hazard ratio; SCC, squamous cell carcinoma.