TY - JOUR T1 - Endometrial cancer outcomes among non-Hispanic US born and Caribbean born black women JF - International Journal of Gynecologic Cancer JO - Int J Gynecol Cancer SP - 897 LP - 903 DO - 10.1136/ijgc-2019-000347 VL - 29 IS - 5 AU - Matthew Schlumbrecht AU - Marilyn Huang AU - Judith Hurley AU - Sophia George Y1 - 2019/06/01 UR - http://ijgc.bmj.com/content/29/5/897.abstract N2 - Purpose Data on endometrial cancer outcomes among immigrant women in the USA are lacking. The objective was to determine the effect of Caribbean nativity on outcomes in black women with endometrial cancer compared with women born in the USA, with attention paid to the effects of tumor grade, sociodemographic factors, and treatment approaches.Methods A review of the institutional cancer registry was performed to identify black, non-Hispanic women with known nativity and treated for endometrial cancer between 2001 and 2017. Sociodemographic, treatment, and outcomes data were collected. Analyses were done using the χ2 test, Cox proportional hazards models, and the Kaplan–Meier method, with significance set at P<0.05.Results 195 women were included in the analysis. High grade histologies were present in a large proportion of both US born (64.5%) and Caribbean born (72.2%) patients. Compared with US born women, those of Caribbean nativity were more likely to be non-smokers (P=0.01) and be uninsured (P=0.03). Caribbean born women had more cases of stage III disease (27.8% versus 12.5%, P<0.01), while carcinosarcoma was more common in US born black women (23.6% versus 10.6%, P=0.05). Caribbean nativity trended towards improvement in overall survival (hazard ratio (HR) 0.65 (0.40–1.07)). Radiation (HR 0.53 (0.29–1.00)) was associated with improved survival while advanced stage (HR 3.81 (2.20–6.57)) and high grade histology (HR 2.34 (1.17–4.72)) were predictive of worse survival.Conclusions The prevalence of high grade endometrial cancer histologies among black women of Caribbean nativity is higher than previously reported. Caribbean nativity may be associated with improved overall survival although additional study is warranted. ER -