PT  - JOURNAL ARTICLE
AU  - L. R. Medeiros
AU  - D. D. Rosa
AU  - M. I. Edelweiss
AU  - A. T. Stein
AU  - M. C. Bozzetti
AU  - A. Zelmanowicz
AU  - P. R. Pohlmann
AU  - L. Meurer
AU  - M. T. Carballo
TI  - Accuracy of frozen-section analysis in the diagnosis of ovarian tumors: a systematic quantitative review
AID  - 10.1136/ijgc-00009577-200503000-00002
DP  - 2005 Feb 01
TA  - International Journal of Gynecologic Cancer
PG  - 192--202
VI  - 15
IP  - 2
4099  - http://ijgc.bmj.com/content/15/2/192.short
4100  - http://ijgc.bmj.com/content/15/2/192.full
SO  - Int J Gynecol Cancer2005 Feb 01; 15
AB  - A quantitative systematic review was performed to estimate the diagnostic accuracy of frozen sections in ovarian tumors. Studies that compared frozen sections and paraffin sections within subjects for diagnosis of ovarian tumors were included. Fourteen primary studies were analyzed, which included 3 659 women. For benign ovarian vs borderline/malignant tumor cases, the occurrence of a positive frozen-section result for benignity (pooled likelihood ratio [LR], 8.7; 95% confidence interval [CI], 7.3–10.4) and posttest probability for benign diagnosis was 95% (95% CI, 94–96%). A positive frozen-section result for malignant vs benign diagnosis (pooled LR, 303; 95% CI, 101–605) increased the probability of ovarian cancer to 98% (95% CI, 97–99%). In borderline vs benign ovarian tumor cases, a positive frozen-section result (pooled LR, 69; 95% CI, 45–106) increased the probability of borderline tumors to 79% (95% CI, 71–85%). In borderline vs malignant ovarian tumor cases, a positive frozen-section result (pooled LR, 18; 95% CI, 13–26) increased the probability of borderline tumors to 51% (95% CI, 42–60%). We conclude that diagnostic accuracy rates for frozen-section analysis is high for malignant and benign ovarian tumors, but the accuracy rates in borderline tumors remain relatively low.