RT Journal Article
SR Electronic
T1 Mechanisms of reversal of adriamycin resistance in human ovarian carcinoma cell line by ultrasound
JF International Journal of Gynecologic Cancer
JO Int J Gynecol Cancer
FD BMJ Publishing Group Ltd
SP 76
OP 81
DO 10.1136/ijgc-00009577-200401000-00009
VO 14
IS 1
A1 T. Yu
A1 X. Huang
A1 K. Hu
A1 J. Bai
A1 Z. Wang
YR 2004
UL http://ijgc.bmj.com/content/14/1/76.abstract
AB The aim of this study was to investigate the reversal of adriamycin resistance in human ovarian cancer cells by ultrasound exposure from perspectives of apoptosis and mdr1 gene. Apoptosis was determined by flow cytometry and mdr1 level by reverse transcription-polymerase chain reaction (RT-PCR). Apoptosis indexes were improved in groups in which ultrasound exposures were applied. RT-PCR did not support that insonation-decreased mdr1 level. These findings suggested that the ultrasound-enhanced therapeutic efficacy was not mediated via modulating gene expression, and ultrasound maybe lowered thresholds for apoptosis and oncosis in chemoresistant ovarian cancer cells.