PT  - JOURNAL ARTICLE
AU  - W.-C. Chang
AU  - B.-C. Sheu
AU  - R.-C. Chen
AU  - S.-N. Chow
AU  - S.-C. Huang
TI  - Depressed host immunity in a case of metachronous primary uterine papillary serous carcinoma and non-Hodgkin's lymphoma
AID  - 10.1136/ijgc-00009577-200409000-00043
DP  - 2004 Aug 01
TA  - International Journal of Gynecologic Cancer
PG  - 1030--1032
VI  - 14
IP  - 5
4099  - http://ijgc.bmj.com/content/14/5/1030.short
4100  - http://ijgc.bmj.com/content/14/5/1030.full
SO  - Int J Gynecol Cancer2004 Aug 01; 14
AB  - Metachronous primary malignant tumors of uterine papillary serous carcinoma (UPSC) and non-Hodgkin's lymphoma (NHL) are rare. UPSC is a clinically aggressive and morphologically distinctive variant of endometrial carcinoma. We describe the clinical features of a 63-year-old patient with UPSC that was found 2 years after chemotherapy for malignant lymphoma of neck, stage IV and 5 months after radiation therapy for recurrence. This patient had undergone staging surgery and postoperative radiation for UPSC. One month after completion of radiotherapy, the patient expired due to persistence of the disease. The association between host immunity and UPSC is rarely described in the literature. Immunological profiles of this patient, with compositional changes of natural killer, B, and T cell, dramatically altered the percentage of CD4+ T cell, CD8+ T cell, and CD4/CD8 ratio, signifying depressed host immunity. Immunological profile of this patient stressed the issue of depressed host immunity and associated malignancies.