TY - JOUR T1 - Adenocarcinoma of mammary-like glands in the vulva successfully treated by weekly paclitaxel JF - International Journal of Gynecologic Cancer JO - Int J Gynecol Cancer SP - 568 LP - 571 DO - 10.1136/ijgc-00009577-200505000-00027 VL - 15 IS - 3 AU - H. Tanaka AU - T. Umekawa AU - K. Nagao AU - A. Ishihara AU - N. Toyoda Y1 - 2005/04/01 UR - http://ijgc.bmj.com/content/15/3/568.abstract N2 - An 87-year-old was referred for gynecologic evaluation of a lesion involving the left labia majus noted 3 years earlier. Fine-needle aspiration cytology revealed clusters with an acinous structure or glandular formation. The tumor appeared as cell clusters with linear arrangements. Histologic examination showed the same morphologic findings as scirrhus type of primary breast carcinoma. Examinations of the breasts and axillary lymph nodes were normal. This disease was diagnosed as an adenocarcinoma arising in mammary-like glands of the vulva. Bone scan showed multiple foci in the sternum, costa, and vertebrae, consistent with metastatic disease. We administered five courses of weekly paclitaxel chemotherapy, which achieved a partial response. There were no severe adverse effects. In our case, the fine-needle aspiration cytology was a rapid and minimally invasive method of diagnosis, and the findings were extremely similar to those of the scirrhus type of primary breast carcinoma. Rapid and accurate diagnosis made with this technique might contribute to a good prognosis in the early-staged cases. Weekly paclitaxel chemotherapy may be one of the safe and effective treatments for this disease with distant metastases, even in extremely aged patients (over 80 years). ER -