@article {Longatto-Filho955, author = {A. Longatto-Filho and M. Er{\v z}en and M. Branca and C. Roteli-Martins and P. Naud and S. F.M. Derchain and L. Hammes and L. O. Sarian and J. F. Bragan{\c c}a and J. Matos and R. Gontijo and T. Lima and M. Y.S. Maeda and S. Tatti and S. Syrj{\"a}nen and G. Dores and A. L{\"O}RINCZ and K. Syrj{\"a}nen}, title = {Human papillomavirus testing as an optional screening tool in low-resource settings of Latin America: experience from the Latin American Screening study}, volume = {16}, number = {3}, pages = {955--962}, year = {2006}, doi = {10.1136/ijgc-00009577-200605000-00001}, publisher = {BMJ Specialist Journals}, abstract = {Hybrid capture II (HC II) test for oncogenic human papillomaviruses (HPV) was carried out in a cohort of 4284 women at their first clinical visit. Overall prevalence of HPV was 17.1\%, decreasing with age from 33.9\% among women below 20 years to only 11.0\% among those older than 41 years. HPV prevalence was significantly higher among current smokers (odds ratio [OR] = 1.31; 95\% CI 1.1{\textendash}1.6), in women with two or more lifetime sexual partners (OR = 1.9; 95\% CI 1.6{\textendash}2.4), and those women with two or more sexual partners during the past 12 months prior to examination (OR = 1.6; 95\% CI 1.2{\textendash}2.2). HPV detection increased in parallel with increasing cytologic abnormality, being highest in women with high-grade squamous intraepithelial lesion (P = 0.001). Specificity of the HPV test in detecting histologically confirmed cervical disease was 85\% (95\% CI 83.9{\textendash}86.1). Sensitivity of the HPV test in detecting histologic abnormalities increased in parallel with disease severity, ranging from 51.5\% for cervical intraepithelial neoplasia (CIN) 1 to 96.5\% for CIN 3 and 100.0\% for cancer, with respective decline of positive predictive value. These data suggest that HPV testing with HC II assay might be a viable screening tool among this population with relatively high prevalence of cervical disease.}, issn = {1048-891X}, URL = {https://ijgc.bmj.com/content/16/3/955}, eprint = {https://ijgc.bmj.com/content/16/3/955.full.pdf}, journal = {International Journal of Gynecologic Cancer} }