PT  - JOURNAL ARTICLE
AU  - L. H. Honorè
AU  - J. Hanson
TI  - Statistical analysis of pathologic risk factors for intramyometrial lymphvascular space involvement in myoinvasive endometrial carcinoma
AID  - 10.1136/ijgc-00009577-200605000-00057
DP  - 2006 Apr 01
TA  - International Journal of Gynecologic Cancer
PG  - 1330--1335
VI  - 16
IP  - 3
4099  - http://ijgc.bmj.com/content/16/3/1330.short
4100  - http://ijgc.bmj.com/content/16/3/1330.full
SO  - Int J Gynecol Cancer2006 Apr 01; 16
AB  - In a retrospective study using univariate analysis, we identified tumor type (nonendometrioid vs endometrioid), depth of myoinvasion (MI), mode of MI (infiltrative vs cohesive), and direct anatomic invasion of the cervical wall from the isthmus as significant positive risk factors for intramyometrial lymphvascular space involvement (LVSI). On multivariate analysis, tumor grade, depth of MI, and mode of MI retained their significance. We created a grid for the relative risks of LVSI with respect to these variables individually or in combination. We suggest that our indirect estimate of the risk of LVSI can help in assessing prognosis and determining the need for adjuvant therapy whenever LVSI is important in clinical decision making, but its pathologic diagnosis is uncertain.