PT - JOURNAL ARTICLE AU - J. L. Belinson AU - Y. L. Qiao AU - R. G. Pretorius AU - W. H. Zhang AU - S. D. Rong AU - M. N. Huang AU - F. H. Zhao AU - L. Y. Wu AU - S. D. Ren AU - R. D. Huang AU - M. F. Washington AU - Q. J. Pan AU - L. Li AU - D. Fife TI - Shanxi Province cervical cancer screening study II: Self-sampling for high-risk human papillomavirus compared to direct sampling for human papillomavirus and liquid based cervical cytology AID - 10.1136/ijgc-00009577-200311000-00013 DP - 2003 Oct 01 TA - International Journal of Gynecologic Cancer PG - 819--826 VI - 13 IP - 6 4099 - http://ijgc.bmj.com/content/13/6/819.short 4100 - http://ijgc.bmj.com/content/13/6/819.full SO - Int J Gynecol Cancer2003 Oct 01; 13 AB - The objective of this study was to compare the sensitivity and specificity of a new method for self-sampling for high risk human papillomavirus (HPV) with direct sampling and liquid based cervical cytology. In Shanxi Province, China, 8,497 women (ages 27–56) underwent a self-sample for HPV using a conical-shaped brush placed into the upper vagina and rotated. Three to sixteen months later the women were screened with liquid-based cytology and direct HPV tests. Subjects with any abnormal test underwent colposcopy and multiple biopsies. Mean age was 40.9 years. 4.4 percent of subjects had ≥CIN II, 26% a positive self-sample and 24% a positive direct test for HPV. The sensitivity for detection of ≥CIN II was 87.5% for self-sampling, and 96.8% for the direct test (P < 0.001). The specificity was 77.2% for the self-sample and 79.7% for the direct test. With an abnormal Pap defined as ASCUS or greater the sensitivity of the Pap for the detection of ≥ CIN II was 88.3% and the specificity was 81.2%. We conclude that self-sampling for HPV is less sensitive for ≥ CIN II than the direct test, but similar to liquid based cytology.