%0 Journal Article %A J. L. Belinson %A Y. L. Qiao %A R. G. Pretorius %A W. H. Zhang %A S. D. Rong %A M. N. Huang %A F. H. Zhao %A L. Y. Wu %A S. D. Ren %A R. D. Huang %A M. F. Washington %A Q. J. Pan %A L. Li %A D. Fife %T Shanxi Province cervical cancer screening study II: Self-sampling for high-risk human papillomavirus compared to direct sampling for human papillomavirus and liquid based cervical cytology %D 2003 %R 10.1136/ijgc-00009577-200311000-00013 %J International Journal of Gynecologic Cancer %P 819-826 %V 13 %N 6 %X The objective of this study was to compare the sensitivity and specificity of a new method for self-sampling for high risk human papillomavirus (HPV) with direct sampling and liquid based cervical cytology. In Shanxi Province, China, 8,497 women (ages 27–56) underwent a self-sample for HPV using a conical-shaped brush placed into the upper vagina and rotated. Three to sixteen months later the women were screened with liquid-based cytology and direct HPV tests. Subjects with any abnormal test underwent colposcopy and multiple biopsies. Mean age was 40.9 years. 4.4 percent of subjects had ≥CIN II, 26% a positive self-sample and 24% a positive direct test for HPV. The sensitivity for detection of ≥CIN II was 87.5% for self-sampling, and 96.8% for the direct test (P < 0.001). The specificity was 77.2% for the self-sample and 79.7% for the direct test. With an abnormal Pap defined as ASCUS or greater the sensitivity of the Pap for the detection of ≥ CIN II was 88.3% and the specificity was 81.2%. We conclude that self-sampling for HPV is less sensitive for ≥ CIN II than the direct test, but similar to liquid based cytology. %U https://ijgc.bmj.com/content/ijgc/13/6/819.full.pdf