RT Journal Article SR Electronic T1 Significance of microvascular density (MVD) in cervical cancer recurrence JF International Journal of Gynecologic Cancer JO Int J Gynecol Cancer FD BMJ Publishing Group Ltd SP 856 OP 862 DO 10.1136/ijgc-00009577-200311000-00018 VO 13 IS 6 A1 D. Cantu De León A1 C. Lopez-Graniel A1 M. Frias Mendivil A1 G. Chanona Vilchis A1 C. Gomez A1 J. De La Garza Salazar YR 2003 UL http://ijgc.bmj.com/content/13/6/856.abstract AB The purpose of this retrospective study of 118 patients with squamous cell cervical cancer from January 1990 to December 1993 was to evaluate angiogenesis as predictive factor of recurrence in cervical cancer stages II–III treated with standard radiotherapy. Microvessel density (MVD) was evaluated and correlated with other prognostic factors. MVD was greater than 20 in 67.8% of patients with recurrence (P = 0.002) in comparison to 39% of patients without. Disease-free survival was shorter in stage IIA and MVD >20 (P = 0.0193) as well as for stage IIB (P < 0.05), but not for IIIB (P = 0.1613). Global survival was significantly shorter when MVD was >20 (P = 0.0316). For stage IIA and MVD >20 survival was shorter (P = 0.0008) for stage IIB (P < 0.05) but not for IIIB (P = 0.14). Patients younger than 40 years and MVD >20 had poorer disease-free interval and survival (P = 0.0029). MVD in patients with squamous cell cervical cancer stage II and age younger than 40 may play a role in predicting recurrence and survival.