RT Journal Article
SR Electronic
T1 Is bacterial vaginosis associated with cervical intraepithelial neoplasia?
JF International Journal of Gynecologic Cancer
JO Int J Gynecol Cancer
FD BMJ Publishing Group Ltd
SP 159
OP 163
DO 10.1136/ijgc-00009577-200303000-00010
VO 13
IS 2
A1 D. C. M. Boyle
A1 S. E. Barton
A1 S. Uthayakumar
A1 P. E. Hay
A1 J. W. Pollock
A1 P. J. Steer
A1 J. R. Smith
YR 2003
UL http://ijgc.bmj.com/content/13/2/159.abstract
AB Previous research has produced conflicting results regarding the association of bacterial vaginosis (BV) and cervical intraepithelial neoplasia (CIN). These studies have been weakened in their conclusions mainly by failure to adequately control for the presence of sexually transmitted infections (STIs). One proposed mechanism suggesting that carcinogenic nitrosamines acting either independently or via human papilloma virus (HPV) has not been fully tested previously. We undertook a prospective, case-controlled, cross-sectional study where the presence of STIs, in particular human papillomavirus (HPV) which is known to be associated with the development of CIN, was controlled for. Women with BV were not found to have CIN more frequently than women with normal vaginal flora and the quantities of nitrosamines produced by women with BV did not differ significantly from women without BV. We thus found that BV is not associated with CIN.