TY - JOUR T1 - Is bacterial vaginosis associated with cervical intraepithelial neoplasia? JF - International Journal of Gynecologic Cancer JO - Int J Gynecol Cancer SP - 159 LP - 163 DO - 10.1136/ijgc-00009577-200303000-00010 VL - 13 IS - 2 AU - D. C. M. Boyle AU - S. E. Barton AU - S. Uthayakumar AU - P. E. Hay AU - J. W. Pollock AU - P. J. Steer AU - J. R. Smith Y1 - 2003/02/01 UR - http://ijgc.bmj.com/content/13/2/159.abstract N2 - Previous research has produced conflicting results regarding the association of bacterial vaginosis (BV) and cervical intraepithelial neoplasia (CIN). These studies have been weakened in their conclusions mainly by failure to adequately control for the presence of sexually transmitted infections (STIs). One proposed mechanism suggesting that carcinogenic nitrosamines acting either independently or via human papilloma virus (HPV) has not been fully tested previously. We undertook a prospective, case-controlled, cross-sectional study where the presence of STIs, in particular human papillomavirus (HPV) which is known to be associated with the development of CIN, was controlled for. Women with BV were not found to have CIN more frequently than women with normal vaginal flora and the quantities of nitrosamines produced by women with BV did not differ significantly from women without BV. We thus found that BV is not associated with CIN. ER -