PT  - JOURNAL ARTICLE
AU  - A. Tripathi (Bhar)
AU  - S. Banerjee
AU  - A. Roy
AU  - S. Roychowdhury
AU  - C. K. Panda
TI  - Alterations of the P16 gene in uterine cervical carcinoma from Indian patients
AID  - 10.1136/ijgc-00009577-200307000-00011
DP  - 2003 Jun 01
TA  - International Journal of Gynecologic Cancer
PG  - 472--479
VI  - 13
IP  - 4
4099  - http://ijgc.bmj.com/content/13/4/472.short
4100  - http://ijgc.bmj.com/content/13/4/472.full
SO  - Int J Gynecol Cancer2003 Jun 01; 13
AB  - In our analysis, alterations in the P16 tumor suppressor gene were seen in 33% (15/46) of sampled uterine cervical lesions. Among the alterations, mutations in P16 were detected in 15% (7/46) of the samples. One mutation occurred at intron 1/exon 2 splice junction. All the other mutations were in exon 2 with three of them as silent mutations. The promoter hypermethylation and homozygous deletion of P16 gene were detected in 6.5% (3/46) and 8.7% (4/46) of the samples respectively. Loss of heterozygosity and microsatellite size alterations at the P16 locus were seen in 17% (8/46) of the samples. HPV16/18 infection was detected in 76% (35/46) of the samples. But no association was found between P16 alterations and HPV infection. Thus, it seems that P16 inactivation may be associated with the development of some uterine cervical carcinoma.