PT  - JOURNAL ARTICLE
AU  - Mitchell, H.
AU  - Hocking, J.
TI  - Influences on the risk of recurrent high grade cervical abnormality
AID  - 10.1136/ijgc-00009577-200211000-00007
DP  - 2002 Oct 01
TA  - International Journal of Gynecologic Cancer
PG  - 728--734
VI  - 12
IP  - 6
4099  - http://ijgc.bmj.com/content/12/6/728.short
4100  - http://ijgc.bmj.com/content/12/6/728.full
SO  - Int J Gynecol Cancer2002 Oct 01; 12
AB  - The objective of this study is to determine the risk of recurrent abnormality after a first episode of high-grade epithelial abnormality and its evolution over time in a population setting. Two cohorts were established from a statewide registry. The cervical intraepithelial neoplasia (CIN) cohort comprised 6849 women with a biopsy of CIN 2, 2/3 or 3 (squamous or glandular) during 1990–92. A cohort of 6857 women with negative cytology during 1990–92 was used for comparison.The CIN cohort had a significantly greater rate of subsequent high-grade epithelial abnormality than the negative cohort. The risk increased with age. For women over 50 years at the incident biopsy, the rate ratio for subsequent high-grade epithelial abnormality was 24.45 (95% CI, 7.2, 84.3). The rate of subsequent high-grade epithelial abnormality was greater if the incident biopsy was CIN 3 (rate 13.50 per 1000 person years [95% CI, 12.5, 14.6]) rather than CIN 2 or 2/3 (rate 7.83 per 1000 person years [95% CI, 7.1, 8.7]). The rate ratio for subsequent invasive cancer was 9.46 (95% CI, 2.5, 35.3) when the CIN cohort was compared with the negative cohort. We conclude the risk of recurrent high-grade epithelial abnormality is related to the age and degree of abnormality on the incident biopsy. Screening policies should acknowledge the risk does not diminish with time.