TY - JOUR T1 - Systemic treatment policies in ovarian cancer: the next 10 years JF - International Journal of Gynecologic Cancer JO - Int J Gynecol Cancer SP - 231 LP - 240 DO - 10.1136/ijgc-00009577-200311001-00017 VL - 13 IS - Suppl 2 AU - J. J. Biagi AU - E. A. Eisenhauer Y1 - 2003/10/01 UR - http://ijgc.bmj.com/content/13/Suppl_2/231.abstract N2 - Over the past two decades, the development of treatment policies and practice standards has become formalized. In ovarian cancer, most attention has been focused on the development of policies for front-line systemic treatment, using survival as the major outcome that should drive change. This review summarizes the evidence that supported the emergence of paclitaxel–carboplatin as a widely used standard of care for front-line therapy and some of the contradictory data from randomized studies. Furthermore, recently completed or ongoing randomized studies of the addition of a third cytotoxic agent to paclitaxel–carboplatin are summarized. Finally, some novel noncytotoxic approaches are discussed. New standards of care and treatment policies in the next decade will be based on high-quality evidence of improved survival from controlled studies. Many such trials are now ongoing or planned. ER -