TY - JOUR T1 - Association of Survivin Gene Polymorphism With Endometrial Cancer JF - International Journal of Gynecologic Cancer JO - Int J Gynecol Cancer SP - 35 LP - 37 DO - 10.1097/IGC.0b013e318229902c VL - 22 IS - 1 AU - Parisa Zahedi AU - Soheila Aminimoghaddam AU - Forough A. Sayahpour AU - Vahid Haghpanah AU - Parvin Amiri AU - Forozandeh Fereidoni AU - Elnaz Mahrampour AU - Bagher Larijani AU - Javad Tavakkoly-Bazzaz AU - Mahsa M. Amoli Y1 - 2012/01/01 UR - http://ijgc.bmj.com/content/22/1/35.abstract N2 - Objective Survivin is an inhibitor of apoptosis protein, which is up-regulated in endometrial cancer (EC). A promoter region polymorphism (−31G/C) in the survivin gene has been reported as a modulator of gene expression. The aim of this study was to explore the frequency of survivin −31G/C polymorphism in tumor tissues from patients with EC in an Iranian population compared to that of healthy controls.Materials and Methods Paraffin-embedded tissue sections from patients diagnosed with EC (n = 31) and healthy controls (n = 30) were examined. Genotyping for survivin −31G/C polymorphism was performed using polymerase chain reaction (PCR) restriction fragment length polymorphism (RFLP).Results The presence of allele C was found to be significantly increased in EC tissues compared to the healthy tissues (GG vs GC + CC, P = 0. 01; OR, 3.6; 95% CI, 1.1–11.9).Conclusion Our data are in keeping with a previous finding regarding the role of survivin gene polymorphism in malignancies. This finding highlights the role of survivin in pathogenesis of various carcinomas, which might have therapeutic implications. ER -