RT Journal Article
SR Electronic
T1 Association of Survivin Gene Polymorphism With Endometrial Cancer
JF International Journal of Gynecologic Cancer
JO Int J Gynecol Cancer
FD BMJ Publishing Group Ltd
SP 35
OP 37
DO 10.1097/IGC.0b013e318229902c
VO 22
IS 1
A1 Parisa Zahedi
A1 Soheila Aminimoghaddam
A1 Forough A. Sayahpour
A1 Vahid Haghpanah
A1 Parvin Amiri
A1 Forozandeh Fereidoni
A1 Elnaz Mahrampour
A1 Bagher Larijani
A1 Javad Tavakkoly-Bazzaz
A1 Mahsa M. Amoli
YR 2012
UL http://ijgc.bmj.com/content/22/1/35.abstract
AB Objective Survivin is an inhibitor of apoptosis protein, which is up-regulated in endometrial cancer (EC). A promoter region polymorphism (−31G/C) in the survivin gene has been reported as a modulator of gene expression. The aim of this study was to explore the frequency of survivin −31G/C polymorphism in tumor tissues from patients with EC in an Iranian population compared to that of healthy controls.Materials and Methods Paraffin-embedded tissue sections from patients diagnosed with EC (n = 31) and healthy controls (n = 30) were examined. Genotyping for survivin −31G/C polymorphism was performed using polymerase chain reaction (PCR) restriction fragment length polymorphism (RFLP).Results The presence of allele C was found to be significantly increased in EC tissues compared to the healthy tissues (GG vs GC + CC, P = 0. 01; OR, 3.6; 95% CI, 1.1–11.9).Conclusion Our data are in keeping with a previous finding regarding the role of survivin gene polymorphism in malignancies. This finding highlights the role of survivin in pathogenesis of various carcinomas, which might have therapeutic implications.