PT  - JOURNAL ARTICLE
AU  - Cong Li
AU  - Junjun Liu
AU  - Renbo Lu
AU  - Ge Yu
AU  - Xiaochuan Wang
AU  - Yulan Zhao
AU  - Hongtao Song
AU  - Ping Lin
AU  - Xicai Sun
AU  - Xiaoguang Yu
AU  - Yuan Zhang
AU  - Xiaoming Ning
AU  - Jingshu Geng
TI  - AEG -1 Overexpression: A Novel Indicator for Peritoneal Dissemination and Lymph Node Metastasis in Epithelial Ovarian Cancers
AID  - 10.1097/IGC.0b013e3182145561
DP  - 2011 Apr 01
TA  - International Journal of Gynecologic Cancer
PG  - 602--608
VI  - 21
IP  - 4
4099  - http://ijgc.bmj.com/content/21/4/602.short
4100  - http://ijgc.bmj.com/content/21/4/602.full
SO  - Int J Gynecol Cancer2011 Apr 01; 21
AB  - Objective: Despite advances in chemotherapy and cytoreductive surgery, ovarian cancer remains the most lethal gynecological malignancy with a 5-year survival rate of 25% to 30% in advanced stage disease. Our purpose is to evaluate whether astrocyte elevated gene-1 (AEG-1) is a novel predictor of peritoneal dissemination and lymph node metastasis in epithelial ovarian cancer (EOC), which was not previously studied by others.Materials and Methods: Through immunohistochemical and Western blot analysis, AEG-1 expression was evaluated in 25 normal ovarian and 157 EOC specimens. The relationship between AEG-1 expression and EOC metastasis was determined by univariate and multivariate analyses.Results: Western blotting analysis revealed that AEG-1 was overexpressed in metastatic tissues from patients with ovarian cancers. Immunohistochemistry results showed that 83 (95.4%) presented peritoneal dissemination; 41 (47.1%) had lymph node metastasis among 87 patients with AEG-1 overexpression. Univariate and multivariate logistic regression analyses demonstrated that AEG-1 overexpression correlated with peritoneal dissemination and lymph node metastasis in EOC. We further found that the positive and specificity predictive value of AEG-1 staining were better for peritoneal metastasis, whereas the negative and sensitivity predictive value of AEG-1 staining were better for lymph node metastasis. The odds ratio of high-to-low expression for peritoneal dissemination was 8.541 (95% confidence interval, 2.561-37.461), and that for lymph node metastasis was 9.581 (95% confidence interval, 2.613-23.214).Conclusions: The present findings indicate that AEG-1 is overexpressed in a great portion of EOC patients with peritoneal dissemination and/or lymph node metastasis and may be clinically useful for predicting metastasis in EOC. Our findings might provide some benefits for metastatic EOC patients in the clinic.