RT Journal Article
SR Electronic
T1 Conservative Treatment of Stage IA1 Adenocarcinoma of the Uterine Cervix With a Long-Term Follow-Up
JF International Journal of Gynecologic Cancer
JO Int J Gynecol Cancer
FD BMJ Publishing Group Ltd
SP 1063
OP 1066
DO 10.1111/IGC.0b013e3181e768b6
VO 20
IS 6
A1 Tetsuro Yahata
A1 Koji Nishino
A1 Katsunori Kashima
A1 Masayuki Sekine
A1 Kazuyuki Fujita
A1 Motoi Sasagawa
A1 Shigeru Honma
A1 Shoji Kodama
A1 Kenichi Tanaka
YR 2010
UL http://ijgc.bmj.com/content/20/6/1063.abstract
AB Objectives: The adenocarcinoma of the uterine cervix tends to arise in women of childbearing age. Conservative treatment by conization is an alternative to a hysterectomy that allows future pregnancy; however, much less is known about the management of adenocarcinoma because of its rarity and relatively short time frame of follow-up. The purpose of this study was to determine the long-term outcome of patients treated by conization alone.Methods: All patients diagnosed to have FIGO (International Federation of Gynecology and Obstetrics) stage IA1 cervical adenocarcinoma between 1990 and 2004 with more than 5 years' follow-up at 2 institutions were reviewed. Information was abstracted on clinical data including margin status of conization and recurrence.Results: Twenty-seven patients were identified, and 10 patients who expressed a strong desire to preserve fertility were offered a conization and careful surveillance without hysterectomy. The median age was 35 years, and 40% were nulliparous. All tumors were endocervical-type adenocarcinoma, and all tumors were grade 1. None had lymphovascular space invasion. Two patients had a repeated conization because of a positive margin. No recurrence was observed during an average follow-up of 75 months.Conclusions: Although further studies on the management of microinvasive cervical adenocarcinoma are desirable, conization seems to be acceptable treatment modality for patients with stage IA1 cervical adenocarcinoma who desire to preserve their fertility. A careful and long-term follow-up is needed because of lack of sufficient evidence for the safety of this treatment.