TY - JOUR T1 - Prognostic Factors for Survival in Patients With Recurrent Cervical Cancer Previously Treated With Radiotherapy JF - International Journal of Gynecologic Cancer JO - Int J Gynecol Cancer SP - 834 LP - 840 DO - 10.1111/IGC.0b013e3181dcadd1 VL - 20 IS - 5 AU - Seiji Mabuchi AU - Fumiaki Isohashi AU - Yasuo Yoshioka AU - Kumiko Temma AU - Takashi Takeda AU - Toshiya Yamamoto AU - Takayuki Enomoto AU - Kenichirou Morishige AU - Takehiro Inoue AU - Tadashi Kimura Y1 - 2010/06/01 UR - http://ijgc.bmj.com/content/20/5/834.abstract N2 - Introduction: The aim of this study was to identify the prognostic factors and to establish a model for the prediction of life expectancy in patients with recurrent cervical cancer that had previously been treated with radiotherapy.Methods: The records of consecutive women with recurrent cervical cancer after radiotherapy were retrospectively reviewed. Primary disease, follow-up, and recurrence data were collected. Univariate and multivariate analyses of prognostic factors of survival were performed.Results: A total of 162 patients were included in our database. The median survival after recurrence was 15 months. Multivariate analysis revealed that symptom status, the site of relapse, prior chemoradiotherapy, and treatment modality were significant prognostic factors in terms of survival after recurrence. Patient survival was inversely correlated with the number of these prognostic factors. When the patients were divided into 3 prognostic groups, (low risk: patients with no poor prognostic factors; intermediate: patients with one poor prognostic factor; and high-risk: patients with more than 2 poor prognostic factors), the patients in the high-risk group had a significantly shorter survival (median, 10 months) than those with one risk factor (median, 20 months) or no risk factors (median, 36 months).Conclusions: Symptom status, the site of relapse, prior chemoradiotherapy, and treatment modality are significant prognostic factors in patients with recurrent cervical cancer that had previously been treated with radiotherapy. Our prognostic model, composed of 4 clinical variables, may enable physicians to predict survival more accurately.Abbreviations: CT - Computed tomography, PET-CT - Positron emission tomography in combination with computed tomography, ISBT - Interstitial brachytherapy, DFI - Disease-free interval ER -