RT Journal Article
SR Electronic
T1 Prospective Validation Study of a Predictive Score for Operability of Recurrent Ovarian Cancer: The Multicenter Intergroup Study DESKTOP II. A Project of the AGO Kommission OVAR, AGO Study Group, NOGGO, AGO-Austria, and MITO
JF International Journal of Gynecologic Cancer
JO Int J Gynecol Cancer
FD BMJ Publishing Group Ltd
SP 289
OP 295
DO 10.1097/IGC.0b013e31820aaafd
VO 21
IS 2
A1 Philipp Harter
A1 Jalid Sehouli
A1 Alexander Reuss
A1 Annette Hasenburg
A1 Giovanni Scambia
A1 David Cibula
A1 Sven Mahner
A1 Ignace Vergote
A1 Alexander Reinthaller
A1 Alexander Burges
A1 Lars Hanker
A1 Martin Pölcher
A1 Christian Kurzeder
A1 Ulrich Canzler
A1 Karl Ulrich Petry
A1 Andreas Obermair
A1 Edgar Petru
A1 Barbara Schmalfeldt
A1 Domenica Lorusso
A1 Andreas du Bois
YR 2011
UL http://ijgc.bmj.com/content/21/2/289.abstract
AB Purpose: The DESKTOP I trial proposed a score for the prediction of complete cytoreduction in recurrent ovarian cancer. Resectability was assumed if 3 factors were present: (1) complete resection at first surgery, (2) good performance status, and (3) absence of ascites. The DESKTOP II trial was planned to verify this hypothesis prospectively in a multicenter setting.Methods: Participating centers prospectively enrolled all consecutive patients with platinum-sensitive first or second relapse. The score was applied to all patients, but centers were free to decide on therapy. All further therapies were documented, and the outcome of patients was analyzed. A 75% complete resection rate in 110 prospectively classified patients had to be achieved to confirm a positive predictive value of 2 or higher of 3 with 95% probability.Results: A total of 516 patients were screened within 19 months; of these, 261 patients (51%) were classified as score positive, and 129 patients with a positive score and first relapse were operated on. The rate of complete resection was 76%, thus confirming the validity of this score regarding positive prediction of complete resectability in 2 or more of 3 patients. Complication rates were moderate including second operations in 11% and perioperative mortality in 0.8%.Conclusions: This score is the first prospectively validated instrument to positively predict surgical outcome in recurrent ovarian cancer. It can aid in the selection of patients who might benefit from secondary cytoreductive surgery and will be enrolled in the recently started randomized prospective DESKTOP III trial investigating the role of surgery in recurrent platinum-sensitive ovarian cancer.