PT  - JOURNAL ARTICLE
AU  - An Coosemans
AU  - Ben Van Calster
AU  - Godelieve Verbist
AU  - Philippe Moerman
AU  - Ignace Vergote
AU  - Stefaan W. Van Gool
AU  - Frédéric Amant
TI  - <em>Wilms Tumor Gene 1</em> (<em>WT1</em>) is a Prognostic Marker in High-Grade Uterine Sarcoma
AID  - 10.1097/IGC.0b013e318207cab5
DP  - 2011 Jan 01
TA  - International Journal of Gynecologic Cancer
PG  - 302--308
VI  - 21
IP  - 2
4099  - http://ijgc.bmj.com/content/21/2/302.short
4100  - http://ijgc.bmj.com/content/21/2/302.full
SO  - Int J Gynecol Cancer2011 Jan 01; 21
AB  - Introduction: Wilms tumor gene 1 (WT1) contributes to uterine sarcoma tumor biology. In this study, we aimed to clarify the prognostic value of WT1.Methods: A retrospective clinical and histopathological review of 71 women with high-grade uterine sarcoma (leiomyosarcoma [n = 24], undifferentiated sarcoma [n = 9]), and carcinosarcoma (n = 38) was performed. Patients were followed up for at least 12 months. Wilms tumor gene 1 expression was determined by immunohistochemistry. Data on recurrence (progression-free survival) and overall survival (OS) were available for all patients. Univariate and multivariate analyses of WT1 expression were carried out using Kaplan-Meier curves and Cox regression, respectively.Results: Forty-nine (69%) tumors were WT1 positive. Forty-seven (66%) patients died of the disease, with a median OS time of 22 months. Wilms tumor gene 1 was a predictor of survival in the univariate analysis: the hazard ratio of WT1 positivity was 2.44 (95% confidence interval, 1.34-4.71) for progression-free survival and 2.48 (95% confidence interval, 1.26-4.90) for OS. Multivariate analysis including stage, age, tumor size, and sarcoma subtype identified only stage and WT1 positivity as independent prognostic markers for survival.Conclusions: The identification of WT1 as a prognostic marker confirms its role in high-grade uterine sarcoma and carcinosarcoma tumor biology.