PT - JOURNAL ARTICLE AU - Vieri Scotti AU - Simona Borghesi AU - Icro Meattini AU - Calogero Saieva AU - Francesca Rossi AU - Alessia Petrucci AU - Alessandra Galardi AU - Lorenzo Livi AU - Benedetta Agresti AU - Massimiliano Fambrini AU - Mauro Marchionni AU - Giampaolo Biti TI - Postoperative Radiotherapy in Stage I/II Endometrial Cancer: Retrospective Analysis of 883 Patients Treated at the University of Florence AID - 10.1111/IGC.0b013e3181f8fa26 DP - 2010 Nov 01 TA - International Journal of Gynecologic Cancer PG - 1540--1548 VI - 20 IP - 9 4099 - http://ijgc.bmj.com/content/20/9/1540.short 4100 - http://ijgc.bmj.com/content/20/9/1540.full SO - Int J Gynecol Cancer2010 Nov 01; 20 AB - Introduction: The efficacy of postoperative radiotherapy (RT) in the treatment of early-stage endometrial carcinoma (EC) is still under debate. This study was aimed to review the outcome and adverse effects in patients treated for EC with postoperative RT at a single center.Methods: A total of 883 patients with pathological stages I to II EC were retrospectively analyzed. Surgery consisted of total abdominal hysterectomy and bilateral salpingo-oophorectomy, or vaginal hysteroannessiectomy in 532 patients (60.2%) with pelvic lymphadenectomy in 351 patients (39.8%). Seven hundred forty-seven patients (84.6%) underwent whole pelvic RT (WPRT) and 136 (15.4%) combined WPRT and vaginal brachytherapy (BT) boost.Results: At a median follow-up of 9 years (range, 1.2-27.6 years), we observed 10.6% disease relapse. Forty-seven patients experienced local recurrence (LR), and 38 patients experienced distant metastases (DMs). At univariate analysis, age at diagnosis (P < 0.0001), stage (P < 0.04), and histological subtype (P < 0.0001) resulted in significant prognostic factors. At multivariate analysis, histotype emerged as an independent relapse predictor (P = 0.0001). Acute WPRT-related toxicity was mild; diarrhea was the most common adverse effect (19.8%). We recorded long-term adverse effects in 7.8% of the patients.Conclusions: Our study showed that patients with early-stage EC have a good outcome in overall survival and disease-free survival. In our experience, standard surgery (including hysterectomy and bilateral salpingo-oophorectomy followed by WPRT with or without BT) showed an acceptable toxicity profile.