@article {Scotti1540, author = {Vieri Scotti and Simona Borghesi and Icro Meattini and Calogero Saieva and Francesca Rossi and Alessia Petrucci and Alessandra Galardi and Lorenzo Livi and Benedetta Agresti and Massimiliano Fambrini and Mauro Marchionni and Giampaolo Biti}, title = {Postoperative Radiotherapy in Stage I/II Endometrial Cancer: Retrospective Analysis of 883 Patients Treated at the University of Florence}, volume = {20}, number = {9}, pages = {1540--1548}, year = {2010}, doi = {10.1111/IGC.0b013e3181f8fa26}, publisher = {BMJ Specialist Journals}, abstract = {Introduction: The efficacy of postoperative radiotherapy (RT) in the treatment of early-stage endometrial carcinoma (EC) is still under debate. This study was aimed to review the outcome and adverse effects in patients treated for EC with postoperative RT at a single center.Methods: A total of 883 patients with pathological stages I to II EC were retrospectively analyzed. Surgery consisted of total abdominal hysterectomy and bilateral salpingo-oophorectomy, or vaginal hysteroannessiectomy in 532 patients (60.2\%) with pelvic lymphadenectomy in 351 patients (39.8\%). Seven hundred forty-seven patients (84.6\%) underwent whole pelvic RT (WPRT) and 136 (15.4\%) combined WPRT and vaginal brachytherapy (BT) boost.Results: At a median follow-up of 9 years (range, 1.2-27.6 years), we observed 10.6\% disease relapse. Forty-seven patients experienced local recurrence (LR), and 38 patients experienced distant metastases (DMs). At univariate analysis, age at diagnosis (P \< 0.0001), stage (P \< 0.04), and histological subtype (P \< 0.0001) resulted in significant prognostic factors. At multivariate analysis, histotype emerged as an independent relapse predictor (P = 0.0001). Acute WPRT-related toxicity was mild; diarrhea was the most common adverse effect (19.8\%). We recorded long-term adverse effects in 7.8\% of the patients.Conclusions: Our study showed that patients with early-stage EC have a good outcome in overall survival and disease-free survival. In our experience, standard surgery (including hysterectomy and bilateral salpingo-oophorectomy followed by WPRT with or without BT) showed an acceptable toxicity profile.}, issn = {1048-891X}, URL = {https://ijgc.bmj.com/content/20/9/1540}, eprint = {https://ijgc.bmj.com/content/20/9/1540.full.pdf}, journal = {International Journal of Gynecologic Cancer} }