RT Journal Article
SR Electronic
T1 Human Papillomavirus and Cervical Neoplasia Among Female Sex Workers in Madagascar
JF International Journal of Gynecologic Cancer
JO Int J Gynecol Cancer
FD BMJ Publishing Group Ltd
SP 1593
OP 1596
DO 10.1111/IGC.0b013e3181f8c22e
VO 20
IS 9
A1 Smith, Jennifer S.
A1 Van Damme, Kathleen
A1 Randrianjafisamindrakotroka, Nantenaina
A1 Ting, Jie
A1 Rabozakandraina, Tiana
A1 Randrianasolo, Bodo S.
A1 Raharinivo, Mbolatiana
A1 Zanasaotra, Sandrine
A1 Hobbs, Marcia
A1 Rinas, Allen
A1 Cohen, Myron
A1 Gravitt, Patti
A1 Behets, Frieda
YR 2010
UL http://ijgc.bmj.com/content/20/9/1593.abstract
AB Introduction: Human papillomavirus (HPV) prevalence and type distribution were estimated among 90 female sex workers (FSWs) aged 18 to 58 years in Antananarivo, Madagascar.Methods: A total of 90 FSWs aged 18 to 58 years in Antananarivo, Madagascar, were included in this study. Information on sexual and behavioral characteristics was obtained via a questionnaire. Exfoliated cervical cell specimens were collected for conventional cytologic examination and HPV DNA testing by polymerase chain reaction. The prevalence rates of HPV DNA and their corresponding 95% confidence intervals were stratified into the following 3 age groups: younger than 25, 25 to 34, and 35 years or older. To assess the association between HPV DNA positivity and sociodemographic and sexual behavioral factors, age-adjusted odds ratios and 95% confidence intervals were calculated using unconditional logistic regression.Results: The HPV prevalence in exfoliated cervical cell specimens was 36.7%. The most common HPV types found were HPV-52 (11.1%), HPV-31 and -39 (each at 5.6%), and HPV-16 and -83 (each at 3.3%). The prevalence of low-grade squamous intraepithelial lesions was 3.3%, and that of atypical squamous cells of undetermined significance was 18.9%. No high-grade lesion was found. Although associations were imprecise, the HPV prevalence was higher among women who reported younger age at the first intercourse, contraceptive use, a history of cervical lesions, and no history of condom use.Discussion: The prevalence rates of HPV and cervical lesions among FSWs in Madagascar appear higher than among FSW populations from other African countries with a relatively higher population-based prevalence of human immunodeficiency virus infection.