PT  - JOURNAL ARTICLE
AU  - Jennifer S. Smith
AU  - Kathleen Van Damme
AU  - Nantenaina Randrianjafisamindrakotroka
AU  - Jie Ting
AU  - Tiana Rabozakandraina
AU  - Bodo S. Randrianasolo
AU  - Mbolatiana Raharinivo
AU  - Sandrine Zanasaotra
AU  - Marcia Hobbs
AU  - Allen Rinas
AU  - Myron Cohen
AU  - Patti Gravitt
AU  - Frieda Behets
TI  - Human Papillomavirus and Cervical Neoplasia Among Female Sex Workers in Madagascar
AID  - 10.1111/IGC.0b013e3181f8c22e
DP  - 2010 Nov 01
TA  - International Journal of Gynecologic Cancer
PG  - 1593--1596
VI  - 20
IP  - 9
4099  - http://ijgc.bmj.com/content/20/9/1593.short
4100  - http://ijgc.bmj.com/content/20/9/1593.full
SO  - Int J Gynecol Cancer2010 Nov 01; 20
AB  - Introduction: Human papillomavirus (HPV) prevalence and type distribution were estimated among 90 female sex workers (FSWs) aged 18 to 58 years in Antananarivo, Madagascar.Methods: A total of 90 FSWs aged 18 to 58 years in Antananarivo, Madagascar, were included in this study. Information on sexual and behavioral characteristics was obtained via a questionnaire. Exfoliated cervical cell specimens were collected for conventional cytologic examination and HPV DNA testing by polymerase chain reaction. The prevalence rates of HPV DNA and their corresponding 95% confidence intervals were stratified into the following 3 age groups: younger than 25, 25 to 34, and 35 years or older. To assess the association between HPV DNA positivity and sociodemographic and sexual behavioral factors, age-adjusted odds ratios and 95% confidence intervals were calculated using unconditional logistic regression.Results: The HPV prevalence in exfoliated cervical cell specimens was 36.7%. The most common HPV types found were HPV-52 (11.1%), HPV-31 and -39 (each at 5.6%), and HPV-16 and -83 (each at 3.3%). The prevalence of low-grade squamous intraepithelial lesions was 3.3%, and that of atypical squamous cells of undetermined significance was 18.9%. No high-grade lesion was found. Although associations were imprecise, the HPV prevalence was higher among women who reported younger age at the first intercourse, contraceptive use, a history of cervical lesions, and no history of condom use.Discussion: The prevalence rates of HPV and cervical lesions among FSWs in Madagascar appear higher than among FSW populations from other African countries with a relatively higher population-based prevalence of human immunodeficiency virus infection.