PT  - JOURNAL ARTICLE
AU  - Ho, Chih-Ming
AU  - Cheng, Wen-Fang
AU  - Lin, Ming-Chieh
AU  - Chen, Tze-Chien
AU  - Huang, Shih-Hung
AU  - Liu, Fu-Shing
AU  - Chien, Chan-Chao Chang
AU  - Yu, Mu-Hsien
AU  - Wang, Tao-Yeuan
AU  - Hsieh, Chang-Yao
TI  - Prognostic and Predictive Values of E-Cadherin for Patients of Ovarian Clear Cell Adenocarcinoma
AID  - 10.1111/IGC.0b013e3181e68a4d
DP  - 2010 Nov 01
TA  - International Journal of Gynecologic Cancer
PG  - 1490--1497
VI  - 20
IP  - 9
4099  - http://ijgc.bmj.com/content/20/9/1490.short
4100  - http://ijgc.bmj.com/content/20/9/1490.full
SO  - Int J Gynecol Cancer2010 Nov 01; 20
AB  - Objectives: The purpose of the study was to analyze negative versus positive immunoexpression of epithelial cadherin (E-cadherin) and p53 in patients with primary advanced ovarian clear cell adenocarcinoma (OCCA) and its significance in relation to clinical features, progression-free survival and overall survival (OS).Methods and Materials: Protein expression of E-cadherin and p53 was immunohistochemically evaluated in 61 OCCA patients with stages IIC to IV. The clinical factors studied included stage, age, CA-125, residual tumors, and chemotherapy regimens.Results: Positive p53 immunoexpression was 44.8% (26/58) of OCCAs; in contrast, E-cadherin immunoexpression was observed in 75.9% (44/58) of OCCAs. The expected 5-year OS rate of OCCA treated with paclitaxel-based chemotherapy was significantly better than non-paclitaxel-based chemotherapy (40% vs 0%, P = 0.001). The expected 5-year OS rate of OCCA patients with positive E-cadherin immunoexpression (>10%) was also significantly better than patients with negative E-cadherin immunoexpression (≤10%) (35% vs 0%, P = 0.02). The expected 5-year OS rate of those receiving paclitaxel-platinum chemotherapy was not significantly different from platinum-based chemotherapy for those with negative E-cadherin immunoexpression (P = 0.11). The expected 5-year OS rate of those receiving paclitaxel-based chemotherapy was better than non-paclitaxel-based chemotherapy for those with positive E-cadherin immunoexpression (43% vs 0%, P = 0.01). Paclitaxel-based chemotherapy and positive E-cadherin immunoexpression were 2 independent prognostic factors in OS of patients with OCCA (P = 0.01 and 0.04, respectively).Conclusions: E-cadherin is a useful prognostic marker for OCCA patients, and paclitaxel-based chemotherapy can improve survival among patients with positive E-cadherin immunoreactivity.