RT Journal Article
SR Electronic
T1 No Association Between Serum Paraoxonase, Arylesterase Activities, and Hydatidiform Mole
JF International Journal of Gynecologic Cancer
JO Int J Gynecol Cancer
FD BMJ Publishing Group Ltd
SP 149
OP 152
DO 10.1097/IGC.0b013e3182021c59
VO 21
IS 1
A1 Ozturk, Ebru
A1 Balat, Ozcan
A1 Dikensoy, Ebru
A1 Ugur, Mete Gurol
A1 Ozcan, Caglayan
A1 Aydin, Abdullah
A1 Erel, Ozcan
A1 Kul, Seval
YR 2011
UL http://ijgc.bmj.com/content/21/1/149.abstract
AB Background: In this study, we aimed to evaluate the association between hydatidiform mole (HM) and paraoxonase 1 (PON1) activity and phenotyping in comparison with healthy subjects (both pregnant and nonpregnant women).Methods: Eighty women were enrolled in this study. Of these, 26 had HM (group 1). Twenty-seven healthy women in the first trimester of pregnancy with a single viable fetus were included in the study as control subjects (group 2). The remaining 27 subjects were healthy nonpregnant women who also participated as control subjects (group 3). Paraoxonase and arylesterase activities were measured using commercially available kits (Relassay, Gaziantep, Turkey). Paraoxonase activity measurements were performed both in the absence (basal activity) and presence of NaCl (salt-stimulated activity). The phenotype distribution of PON1 activity was determined by the double-substrate method.Results: Basal and salt-stimulated paraoxonase and arylesterase activities were not significantly different between the HM, healthy pregnant control, and healthy nonpregnant control groups. Hence, PON1 phenotype distribution of the subjects was not significantly different between these 3 groups.Conclusions: We determined no association between HM (complete or partial) and PON1 activity and phenotyping in comparison with pregnant and nonpregnant healthy subjects. Further studies including metastatic or invasive HM are needed.