TY - JOUR T1 - A pure nongestational choriocarcinoma of the ovary diagnosed with short tandem repeat analysis: case report and review of the literature JF - International Journal of Gynecologic Cancer JO - Int J Gynecol Cancer SP - 254 LP - 258 DO - 10.1111/j.1525-1438.2006.00764.x VL - 17 IS - 1 AU - E. Yamamoto AU - K. Ino AU - T. Yamamoto AU - S. Sumigama AU - A. Nawa AU - S. Nomura AU - F. Kikkawa Y1 - 2007/01/01 UR - http://ijgc.bmj.com/content/17/1/254.abstract N2 - Nongestational pure choriocarcinoma of the ovary is a very rare germ cell tumor. Except in women before menarche, determination of the origin is very difficult without genetic analysis. We present a pure nongestational choriocarcinoma arising in the left ovary of a 19-year-old woman. Following surgery, pathologic findings of the tumor demonstrated pure choriocarcinoma without combination of other germ cell tumor elements. We confirmed its nongestational origin by DNA polymorphism analysis at 15 short tandem repeat loci. Multiple courses of chemotherapy with methotrexate, etoposide, and actinomycin-D were effective for this case. DNA polymorphism analysis is useful to determine genetic origin in pure choriocarcinoma of the ovary ER -