RT Journal Article
SR Electronic
T1 Coexpression of human chorionic gonadotropin beta subunit and its receptor in nontrophoblastic gynecological cancer
JF International Journal of Gynecologic Cancer
JO Int J Gynecol Cancer
FD BMJ Publishing Group Ltd
SP 1102
OP 1107
DO 10.1111/j.1525-1438.2007.01151.x
VO 18
IS 5
A1 Jankowska, A.
A1 Andrusiewicz, M.
A1 Grabowski, J.
A1 Nowak-Markwitz, E.
A1 Warchol, J. B.
YR 2008
UL http://ijgc.bmj.com/content/18/5/1102.abstract
AB A considerable number of biochemical and physiologic studies evaluate the roles of gonadotropins in carcinogenesis. Latest reports show that human chorionic gonadotropin (hCG), and especially its beta subunit, are secreted by a variety of malignant tumors of different origin. However, the mechanism of hCG action and its role in tumor development is not known yet. This study, with the help of reverse transcription-polymerase chain reaction and immunohistochemistry, is an attempt to document the molecular presence of the hCGβ and luteinizing hormone/hCG receptor (LH/hCGR) in the ovarian, endometrial, and uterine cervix cancer tissues. The LH/hCGR, coexpressed with hCGβ, may act as a potential mediator of hCG action in nontrophoblastic gynecological cancers