PT  - JOURNAL ARTICLE
AU  - G. Vazquez-Ortiz
AU  - J. A. García
AU  - C. J. Ciudad
AU  - V. Noé
AU  - S. Peñuelas
AU  - R. LÓPEZ-ROMERO
AU  - P. Mendoza-Lorenzo
AU  - P. Piña-Sánchez
AU  - M. Salcedo
TI  - Differentially expressed genes between high-risk human papillomavirus types in human cervical cancer cells
AID  - 10.1111/j.1525-1438.2007.00831.x
DP  - 2007 Feb 01
TA  - International Journal of Gynecologic Cancer
PG  - 484--491
VI  - 17
IP  - 2
4099  - http://ijgc.bmj.com/content/17/2/484.short
4100  - http://ijgc.bmj.com/content/17/2/484.full
SO  - Int J Gynecol Cancer2007 Feb 01; 17
AB  - Cervical carcinoma (CC) is one of the most common cancers among women worldwide and the first cause of death among the Mexican female population. Human papillomavirus (HPV) infection is the most important etiologic factor for CC. Of the oncogenic types, HPV16 and HPV18 are found in 60–70% of invasive CCs worldwide. HPV18 appears to be associated with a more aggressive form of cervical neoplasia than HPV16 infection. At present, there are no studies on differentially expressed cellular genes between transformed cells harboring HPV16 and HPV18 sequences. Based on previous complementaryDNA microarray data from our group, 13 genes were found to be differentially overexpressed between HPV16- and HPV18-transformed cells. These genes were as follows: E6BP, UBE4A, C20orf14, ATF7, ABCC8, SLC6A12, WASF3, SUV39H1, SPAG8, CCNC, E2FFE, BIRC5, and DEDD. Differential expression of six selected genes was confirmed by real-time reverse transcription–polymerase chain reaction (RT-PCR). All real-time RT-PCRs confirmed differential expression between HPV18 and HPV− samples. The present work identifies genes from signaling pathways triggered by HPV transformation that could be differentially deregulated between HPV16+ and HPV18+ samples.