PT - JOURNAL ARTICLE AU - S. Khunamornpong AU - K. Sukpan AU - P. Suprasert AU - S. Shuangshoti AU - J. Pintong AU - S. Siriaunkgul TI - Epstein-Barr virus–associated smooth muscle tumor presenting as a vulvar mass in an acquired immunodeficiency syndrome patient: a case report AID - 10.1111/j.1525-1438.2007.00989.x DP - 2007 Oct 01 TA - International Journal of Gynecologic Cancer PG - 1333--1337 VI - 17 IP - 6 4099 - http://ijgc.bmj.com/content/17/6/1333.short 4100 - http://ijgc.bmj.com/content/17/6/1333.full SO - Int J Gynecol Cancer2007 Oct 01; 17 AB - Smooth muscle tumors in immunocompromised patients have a strong association with Epstein-Barr virus (EBV) infection. EBV-associated smooth muscle tumors (EBV-SMT) are considered as a distinct group of smooth muscle tumors with different clinicopathologic features from conventional smooth muscle tumors. A 31-year-old female patient presented with a 2-cm mass at the left labium majus, the clinical diagnosis of which was a Bartholin lesion. She had acquired immunodeficiency syndrome diagnosed 29 months before. Excisional biopsy revealed a cellular tumor composed of round- to spindle-shaped cells with mild to moderate nuclear atypia. The tumor cells were immunoreactive for smooth muscle actin and muscle actin (HHF-35). Evidence of EBV infection was confirmed by in situ hybridization for EBV-encoded small RNA-1. To our knowledge, this is the first case of EBV-SMT presenting as a vulvar mass. EBV-SMT should be included in the differential diagnoses of mesenchymal tumor in patients with immunosuppression and in the differential diagnoses of smooth muscle tumor in uncommon sites, including the vulva.