RT Journal Article
SR Electronic
T1 Denser trabecular bone in women with endometrial carcinoma
JF International Journal of Gynecologic Cancer
JO Int J Gynecol Cancer
FD BMJ Publishing Group Ltd
SP 161
OP 168
DO 10.1046/j.1525-1438.1994.04030161.x
VO 4
IS 3
A1 G. MÖLlerstrÖM
A1 A. Lagrelius
A1 K. CarlstrÖM
A1 H.-E. SjÖBerg
YR 1994
UL http://ijgc.bmj.com/content/4/3/161.abstract
AB Bone mineral density (BMD) was measured in the distal radius of patients with endometrial carcinoma (EC). The patients were classified into two subgroups depending on whether earlier hormonal replacement therapy (HRT) was given. Two groups of women were recruited as controls: patients with post-menopausal bleeding for non-malignant reasons (hospital controls) and healthy women, free of gyn-ecologic symptoms (non-hospital controls). The BMD was significantly higher in the cancer patients and also in the hospital controls than in the non-hospital controls. When several possible confounding factors were checked for in a multivariate analysis, BMD still differed between the groups. This could lend support to the hypothesis that patients with EC may have an altered endogenous endocrine status which eventually affects their bone mass. The results also stress the importance of using strictly defined, healthy women as controls.