TY - JOUR T1 - Immunohistochemical determination of estrogen and progesterone receptors and DNA flow cytometry in endometrial cancer JF - International Journal of Gynecologic Cancer JO - Int J Gynecol Cancer SP - 169 LP - 173 DO - 10.1046/j.1525-1438.1994.04030169.x VL - 4 IS - 3 AU - P. K. Heinonen AU - J. Isola AU - T. Kuoppala Y1 - 1994/04/01 UR - http://ijgc.bmj.com/content/4/3/169.abstract N2 - Estrogen and progesterone receptor contents (ER, PR) were assessed by an immunohistochemical method and DNA ploidy and S-phase by flow cytometry in frozen endometrial cancer tissue sections from 39 cases. Comparison of the immunohistochemical and cytosol assays showed 81% and 84% concordance in ER and PR contents, respectively. An aneuploid DNA pattern was identified in 30% and a high S-phase fraction was found in 33% of 36 specimens studied. Negative ER status was associated with aneuploid and high S-phase fraction. A similar association was found between PR status and high S-phase fraction. Combined analysis of immunohistochemical receptor status and DNA flow cytometry in the same sample makes it possible to identify two strong predictive factors in endometrial adenocarcinoma. ER -