RT Journal Article
SR Electronic
T1 Major prognostic factors in ovarian carcinomas
JF International Journal of Gynecologic Cancer
JO Int J Gynecol Cancer
FD BMJ Publishing Group Ltd
SP 155
OP 162
DO 10.1046/j.1525-1438.1991.01040155.x
VO 1
IS 4
A1 H. Haapasalo
A1 Y. Collan
A1 N. B. Atkin
YR 1991
UL http://ijgc.bmj.com/content/1/4/155.abstract
AB Prognostic variables predictive of survival in ovarian carcinoma were studied in 91 patients with stage I–IV disease. Univariate analysis showed that clinical stage (FIGO), presence of ascites, age of patient, histologic type and grade, cellular DNA content, morphometric grade, mitotic activity index, and volume corrected mitotic index (M/V index) were prognostic. Multivariate analysis using a Cox model showed that the stage (best predictor in total material), the M/V index (best predictor in stage I tumors), the DNA content (best predictor in advanced stages), and ascites were independently prognostic. Morphometry and/or DNA cytometry should be standard in the histo-pathological evaluation of ovarian carcinomas.