PT  - JOURNAL ARTICLE
AU  - H. Haapasalo
AU  - Y. Collan
AU  - N. B. Atkin
TI  - Major prognostic factors in ovarian carcinomas
AID  - 10.1046/j.1525-1438.1991.01040155.x
DP  - 1991 Jun 01
TA  - International Journal of Gynecologic Cancer
PG  - 155--162
VI  - 1
IP  - 4
4099  - http://ijgc.bmj.com/content/1/4/155.short
4100  - http://ijgc.bmj.com/content/1/4/155.full
SO  - Int J Gynecol Cancer1991 Jun 01; 1
AB  - Prognostic variables predictive of survival in ovarian carcinoma were studied in 91 patients with stage I–IV disease. Univariate analysis showed that clinical stage (FIGO), presence of ascites, age of patient, histologic type and grade, cellular DNA content, morphometric grade, mitotic activity index, and volume corrected mitotic index (M/V index) were prognostic. Multivariate analysis using a Cox model showed that the stage (best predictor in total material), the M/V index (best predictor in stage I tumors), the DNA content (best predictor in advanced stages), and ascites were independently prognostic. Morphometry and/or DNA cytometry should be standard in the histo-pathological evaluation of ovarian carcinomas.