PT  - JOURNAL ARTICLE
AU  - M. E. Connor
AU  - S. E. Davidson
AU  - P. L Stern
AU  - J. R. Arrand
AU  - C. M.L. West
TI  - Evaluation of multiple biologic parameters in cervical carcinoma: high macrophage infiltration in HPV-associated tumors
AID  - 10.1046/j.1525-1438.1993.03020103.x
DP  - 1993 Feb 01
TA  - International Journal of Gynecologic Cancer
PG  - 103--109
VI  - 3
IP  - 2
4099  - http://ijgc.bmj.com/content/3/2/103.short
4100  - http://ijgc.bmj.com/content/3/2/103.full
SO  - Int J Gynecol Cancer1993 Feb 01; 3
AB  - A number of diverse biologic parameters have been assessed prior to treatment in a series of patients with cervical carcinoma. Factors analyzed were HPV DNA presence, MHC class I expression, expression of the oncofetal antigen 5T4, the proportions of macrophages, lymphocytes and granulocytes in cell suspensions prepared from tumors, in vitro colony-forming efficiency (CFE) and a measure of intrinsic radiosensitivity, surviving fraction at 2 Gy. Several associations were found. First, HPV DNA-negative tumors contained a small, but significant, decreased number of tumor infiltrating macrophages compared with HPV DNA-positive tumors. Secondly, patients with HPV-positive tumors were significantly younger than those where no HPV was detected. Thirdly, loss of one or more specific alleles in MHC class I positive tumors resulted in higher numbers of tumor lymphocytes and CFEs. Finally, strong expression of the 5T4 antigen was related to a reduction in the proportion of macrophages in tumor cell suspensions. In addition, for stage I and II patients expression of the MHC class I molecule was associated with improved survival compared with patients with tumors where loss of expression was seen.