RT Journal Article
SR Electronic
T1 The importance of determining karyotype in premenarchal females with gonadal dysgerminoma: two case reports
JF International Journal of Gynecologic Cancer
JO Int J Gynecol Cancer
FD BMJ Publishing Group Ltd
SP 141
OP 143
DO 10.1111/j.1525-1438.1991.tb00029.x
VO 1
IS 3
A1 Steller, M. A.
A1 Soper, J. T.
A1 Szpak, C. A.
A1 Lanman, J. T.
A1 Clark-Pearson, D. L.
YR 1991
UL http://ijgc.bmj.com/content/1/3/141.abstract
AB Gonadal dysgerminomas developed in two girls, aged 12 and 15 years. Both were initially treated with conservative unilateral gonadectomy. Forty-six, XY gonadal dysgenesis was not suspected in either patient due to the normal appearance of the contralateral gonads and internal female genital organs. One died of a second germ cell malignancy which developed in the contralateral ovary 9½ years later. The diagnosis of 46, XY gonadal dysgenesis was established by karyotype in both patients. Although conservative surgical management is desirable for nulliparous women with unilateral dysgerminomas, the presence of 46, XY gonadal dysgenesis should be suspected in all premenarchal girls with ovarian germ cell malignancies. If karyotyping reveals the presence of an Y chromosome, bilateral gonadectomy is indicated because of the risk that another neoplasm may develop in the contralateral ovary.