PT  - JOURNAL ARTICLE
AU  - Kiyotoki, Takanori
AU  - Nakamura, Keiichiro
AU  - Haraga, Junko
AU  - Omichi, Chiaki
AU  - Ida, Naoyuki
AU  - Saijo, Masayuki
AU  - Nishida, Takeshi
AU  - Kusumoto, Tomoyuki
AU  - Masuyama, Hisashi
TI  - Sarcopenia Is an Important Prognostic Factor in Patients With Cervical Cancer Undergoing Concurrent Chemoradiotherapy
AID  - 10.1097/IGC.0000000000001127
DP  - 2018 Jan 01
TA  - International Journal of Gynecologic Cancer
PG  - 168--175
VI  - 28
IP  - 1
4099  - http://ijgc.bmj.com/content/28/1/168.short
4100  - http://ijgc.bmj.com/content/28/1/168.full
SO  - Int J Gynecol Cancer2018 Jan 01; 28
AB  - Objective This study aimed to investigate the correlation of sarcopenia findings with prognostic factors in patients with cervical cancer (CC) undergoing concurrent chemoradiotherapy (CCRT).Methods We retrospectively collected data on body composition and clinicopathological features from the medical records of 60 patients with CC who underwent CCRT and analyzed correlations between prognosis and changes in body composition as measured by computed tomography (skeletal muscle and iliopsoas muscle [IM]). Statistical analyses were performed using the Mann-Whitney U test. Progression-free survival (PFS) and overall survival (OS) were analyzed using the Kaplan-Meier method. Cox proportional hazard regression was used for univariate and multivariate analyses.Results The median follow-up for all patients who were alive at the last follow-up was 33.5 months (range, 1–104 months). The PFS and OS rates were worse for patients with at least 15.0% than for those with less than 15.0% loss of skeletal muscle and IM from baseline (P < 0.001 for both). Furthermore, multivariate analyses showed that at least 15.0% loss of IM was an independent prognostic factor for PFS and OS (P = 0.002 for both).Conclusions Sarcopenia (≥15.0% loss of IM from baseline) was revealed to be an important prognostic factor in patients with CC undergoing CCRT.