PT  - JOURNAL ARTICLE
AU  - Sallum, Luis Felipe
AU  - Andrade, Liliana
AU  - Bastos Eloy da Costa, Larissa
AU  - Ramalho, Susana
AU  - Ferracini, Amanda Canato
AU  - Natal, Rodrigo de Andrade
AU  - Brito, Angelo Borsarelli Carvalho
AU  - Sarian, Luis Otávio
AU  - Derchain, Sophie
TI  - BRCA1, Ki67, and β-Catenin Immunoexpression Is Not Related to Differentiation, Platinum Response, or Prognosis in Women With Low- and High-Grade Serous Ovarian Carcinoma
AID  - 10.1097/IGC.0000000000001205
DP  - 2018 Mar 01
TA  - International Journal of Gynecologic Cancer
PG  - 437--447
VI  - 28
IP  - 3
4099  - http://ijgc.bmj.com/content/28/3/437.short
4100  - http://ijgc.bmj.com/content/28/3/437.full
SO  - Int J Gynecol Cancer2018 Mar 01; 28
AB  - Objective The purpose of this study was to compare the immunohistochemical expression of BRCA1, Ki67, and β-catenin in women with low-grade (LGSOC) and high-grade serous ovarian carcinomas (HGSOC) and their relationship with clinicopathological features, response to platinum-based chemotherapy, and survival.Methods For this study, 21 LGSOC and 85 HGSOC stage I to IV cases, diagnosed and treated from 1996 to 2013 and followed-up until December 2016, were included. BRCA1, Ki67, and β-catenin expression was assessed using tissue microarray-based immunohistochemistry.Results Women with HGSOC were significantly more likely to have advanced-stage disease (P < 0.001), higher CA125 levels (P < 0.001), postsurgery residual disease (P < 0.01), and higher rates of disease progression and recurrence (P = 0.001). The percentage of women with HGSOC whose tumors expressed Ki67 was significantly higher compared with women with LGSOC (P < 0.001). The expression of BRCA1 and β-catenin did not differ between LGSOC and HGSOC (P = 0.12 and P = 1.00, respectively). The clinicopathological features and the response to platinum-based chemotherapy did not differ according to the BRCA1, Ki67, and β-catenin expression in either group. In HGSOC, only International Federation of Gynecology and Obstetrics stage was independently associated with poor survival (PFS and OS).Conclusions Ki67 expression was significantly higher in HGSOC. BRCA1 and β-catenin expression did not differ between LGSOC and HGSOC samples. BRCA1, Ki67, and β-catenin expression was neither related to clinicopathological features, response to platinum-based chemotherapy, nor survival. Only International Federation of Gynecology and Obstetrics stage remained associated with poor survival in women with HGSOC.