PT  - JOURNAL ARTICLE
AU  - Gunsu Kimyon
AU  - Taner Turan
AU  - Derman Basaran
AU  - Osman Turkmen
AU  - Alper Karalok
AU  - Tolga Tasci
AU  - Gokhan Tulunay
AU  - Mehmet Faruk Kose
TI  - Is Neurosurgery With Adjuvant Radiotherapy an Effective Treatment Modality in Isolated Brain Involvement From Endometrial Cancer?: From Case Report to Analysis
AID  - 10.1097/IGC.0000000000000886
DP  - 2017 Feb 01
TA  - International Journal of Gynecologic Cancer
PG  - 315--325
VI  - 27
IP  - 2
4099  - http://ijgc.bmj.com/content/27/2/315.short
4100  - http://ijgc.bmj.com/content/27/2/315.full
SO  - Int J Gynecol Cancer2017 Feb 01; 27
AB  - Aim The aim of this study was to evaluate the treatment options and post–brain involvement survival (PBIS) of patients with isolated brain involvement from endometrial cancer (EC).Materials and Methods The literature electronic search was conducted from 1972 to May 2016 to identify articles about isolated (without extracranial metastases) brain involvement from EC at recurrence and the initial diagnosis. Forty-eight articles were found. After comprehensive evaluation of case series and case reports, the study included 49 cases.Results The median age of the patients at initial diagnosis was 57 years (range, 40–77 years). Poor differentiation was determined in 36 (73.5%) patients. Thirty-five (71.4%) patients had a single brain lesion. Lesion was found in the supratentorial part of the brain in 33 (67.3%) patients. Median PBIS for all cohorts was 13 months (range, 0.25–118 months) with 2-year PBIS of 52% and 5-year PBIS of 37%. Age, tumor type, grade, disease-free interval, diagnosis time of brain lesion, localization, and number of brain lesion were not predictive of PBIS. Two-year PBIS was 77% in patients who underwent surgical resection and radiotherapy, whereas it was 19% in the surgical resection–only group, and 20% in the primary radiotherapy–only group (Ps = 0.003 and 0.001, respectively). Chemotherapy was not associated with improved PBIS.Conclusions Although neuroinvasion from EC appears mostly with a disseminated disease, there is a considerable amount of patients with isolated brain involvement who would have a higher chance of curability. Surgery with radiotherapy is the rational current management option, and this improves the survival for isolated brain involvement from EC.