PT - JOURNAL ARTICLE AU - Chiaki Omichi AU - Keiichiro Nakamura AU - Junko Haraga AU - Naoyuki Ida AU - Masayuki Saijo AU - Takeshi Nishida AU - Tomoyuki Kusumoto AU - Hisashi Masuyama TI - The Influence of Adverse Effects on Quality of Life of Survivors of Gynecologic Cancer AID - 10.1097/IGC.0000000000001125 DP - 2017 Nov 01 TA - International Journal of Gynecologic Cancer PG - 2014--2019 VI - 27 IP - 9 4099 - http://ijgc.bmj.com/content/27/9/2014.short 4100 - http://ijgc.bmj.com/content/27/9/2014.full SO - Int J Gynecol Cancer2017 Nov 01; 27 AB - Objective The objective of this observational study was to investigate correlations between adverse effects (lower-extremity lymphedema [LEL], dysuria, and severe gastrointestinal symptoms) and quality of life (QOL) (physical well-being [PWB], social well-being, emotional well-being [EWB], and functional well-being) before treatment, at least 6 weeks after treatment (posttreatment1), and 3 or 6 months after treatment (posttreatment2) of patients with gynecologic cancer (GC).Methods From August 2012 to October 2016, questionnaire responses and clinical data of 75 patients with GC were collected and assessed by treatment received. The χ2 test was used to determine the significance of correlations.Results Participants with LEL had significantly poorer QOL than did those without it in the domains of PWB at posttreatment1 (P = 0.026) and EWB at posttreatment2 (P = 0.020). Moreover, patients with 2 adverse effects (LEL plus dysuria or severe gastrointestinal symptoms) had significantly poorer QOL than did those with no or single adverse effect in the domains of PWB at posttreatment1 and posttreatment2 (posttreatment1: P = 0.049, P = 0.001; posttreatment2: P = 0.002, P = 0.028) and poorer QOL compared with those with no adverse effect in the domain of EWB at posttreatment1 (P = 0.017).Conclusions Poorer QOL in emotional and physical domains is associated with adverse effects of treatment in patients with GC. It is important to consider the effects of radical therapy not only on survival but also on the QOL of survivors.