RT Journal Article SR Electronic T1 Expression of Tissue Factor in Epithelial Ovarian Carcinoma Is Involved in the Development of Venous Thromboembolism JF International Journal of Gynecologic Cancer JO Int J Gynecol Cancer FD BMJ Publishing Group Ltd SP 37 OP 43 DO 10.1097/IGC.0000000000000848 VO 27 IS 1 A1 Manabu Sakurai A1 Koji Matsumoto A1 Masahiko Gosho A1 Akiko Sakata A1 Yoshihiko Hosokawa A1 Yuri Tenjimbayashi A1 Takashi Katoh A1 Ayumi Shikama A1 Haruna Komiya A1 Hiroo Michikami A1 Nobutaka Tasaka A1 Azusa Akiyama-Abe A1 Sari Nakao A1 Hiroyuki Ochi A1 Mamiko Onuki A1 Takeo Minaguchi A1 Hiroyuki Yoshikawa A1 Toyomi Satoh YR 2017 UL http://ijgc.bmj.com/content/27/1/37.abstract AB Objectives Our 2007 study of 32 patients with ovarian cancer reported the possible involvement of tissue factor (TF) in the development of venous thromboembolism (VTE) before treatment, especially in clear cell carcinoma (CCC). This follow-up study further investigated this possibility in a larger cohort.Methods We investigated the intensity of TF expression (ITFE) and other variables for associations with VTE using univariate and multivariate analyses in 128 patients with epithelial ovarian cancer initially treated between November 2004 and December 2010, none of whom had received neoadjuvant chemotherapy. Before starting treatment, all patients were ultrasonographically screened for VTE. The ITFE was graded based on immunostaining of surgical specimens.Results Histological types were serous carcinoma (n = 42), CCC (n = 12), endometrioid carcinoma (n = 15), mucinous carcinoma (n = 53), and undifferentiated carcinoma (n = 6). The prevalence of VTE was significantly higher in CCC (34%) than in non-CCC (17%, P = 0.03). As ITFE increased, the frequencies of CCC and VTE increased significantly (P < 0.001 and P = 0.014, respectively). Multivariate analysis identified TF expression and pretreatment dimerized plasmin fragment D level as significant independent risk factors for VTE development. These factors showed particularly strong impacts on advanced-stage disease (P = 0.021).Conclusions The 2007 cohort was small, preventing multivariate analysis. This study of a larger cohort yielded stronger evidence that the development of VTE in epithelial ovarian cancer may involve TF expression in cancer tissues.